The average cost of prescribed drugs was estimated to be $1,955 in 2016 for those who had annual costs. This was up nearly 31% from 2009. Using medical inflation rates, $1,955 is about $2,086 in 2019 dollars. The median total expense was $326. Average out of pocket expense for the year was $238 for those with prescribed medicines. The average out of pocket expenditure was $401 for those over 65 and $188 for those under 65. Overall median was $51, as insurance covered more of the cost. Statistical Brief 533 by AHRQ (published May 2019) uses MEPS data.